Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 14: 531-534, 1959;
8750-7587/59 $5.00
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Pulmonary blood volume determined by a radioactive tracer technique

Arnold M. Weissler 1, Burley H. McCraw 1, and James V. Warren 1

1 Department of Medicine, Duke University Medical Center, and the Veterans Administration Hospital, Durham, North Carolina

A semiquantitative technique for assaying shifts in intrapulmonary blood volume is described. The method consists of the external monitoring of radioactivity over the anterior thorax after the intravenous administration of radioactive iodinated albumin utilizing a sensitive scintillation counter with a focusing collimator attachment. While this method does not yield the quantitative data of the indicator dilution and body plethysmographic techniques, it offers the advantage of confining observations to the intrapulmonary rather than the intrathoracic blood volume. Employing this technique, the effects of the upright posture, peripheral venous pooling and the Valsalva maneuver have been studied. A fall in estimated pulmonary blood volume was noted with each procedure, averaging 28%, 9% and 11%, respectively, below control levels.

Submitted on January 16, 1959




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