Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 14: 363-367, 1959;
8750-7587/59 $5.00
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In vitro effect of nonindole compounds on oxidative activity of ceruloplasmin

K. M. Hanson 1, D. C. Austin 1, and M. H. Aprison 1

1 Institute of Psychiatric Research and Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana

It has already been shown that, in addition to ascorbic acid, 5-hydroxytryptamine and several other 5-hydroxyindole compounds affect the oxidative activity of ceruloplasmin and serum oxidase. Therefore, an in vitro study of the effect of several other normal metabolites and drugs on this enzyme system was undertaken. It was found that the compounds which affect this reaction fall into two classes. One group (cysteine, penicillamine and ascorbic acid) reacts with the oxidized form of the substrate reducing it back into the original compound, thereby producing a lag period in the reaction. The other group (DOPA and iproniazid) inhibits the reaction, probably by competing with the substrate molecules for the enzyme site.

Submitted on November 17, 1958






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