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J Appl Physiol 14: 311-312, 1959;
8750-7587/59 $5.00
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Effects of pure carbon monoxide gas injection into the peritoneal cavity of dogs

Syrrel S. Wilks 1

1 Department of Physiology and Biophysics, School of Aviation Medicine, USAF, Randolph Air Force Base, Texas

Relatively large quantities of pure carbon monoxide (500 ml) were injected into the peritoneal cavity of normal dogs, CO-acclimatized dogs and altitude-acclimatized dogs. Withdrawal and analysis of the gas at timed intervals revealed a rise in oxygen tension from zero to values which were 2frac12 times the PaOO2. The PiOO2 (intraperitoneal O2 tension) in the acclimatized dogs attained values significantly higher than for the normal dogs. The PiCOCO2 (intraperitoneal CO2 tension) in all dogs approximated the value in normal animals. At no time after the injection did the COHb exceed a 40–50% concentration level. The physiologic mechanism of the observed phenomena is discussed.

Submitted on September 22, 1958






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