Journal of Applied Physiology
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J Appl Physiol 14: 251-254, 1959;
8750-7587/59 $5.00
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Cerebral free amino acids in dogs following infusion of ammonia

B. Eiseman 1, H. Osofsky 1, E. Roberts 1, and B. Jelinek 1

1 Department of Surgery, University of Colorado School of Medicine and the Denver Veterans Administration Hospital, Denver, Colorado and the Department of Biochemistry, City of Hope Medical Center, Duarte, California

In order to clarify the biochemical changes occurring during experimental ammonia intoxication, the free amino acid content of brain tissue has been determined in suitable control dogs and in ten unanesthetized animals receiving bilateral carotid artery infusions of lactate-Ringer's solution containing 1% ammonium hydroxide until coma. The major change in dogs receiving the ammonia infusion was an increase in glutamine content proportionate to the time of the infusion. Occurrence of coma did not appear to be related directly to change in blood pH or to a critical level of carotid arterial ammonia concentration.

Submitted on May 29, 1958






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