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J Appl Physiol 14: 105-108, 1959;
8750-7587/59 $5.00
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‘Alveolar plateau’ of the single breath nitrogen elimination curve in normal subjects

Ingemar Kjellmer 1, Lars Sandqvist 1, and Erik Berglund 1

1 Pulmonary Physiological Laboratory, University Lung Clinic, Renströmska Sjukhuset, Göteborg, Sweden

The single breath N2 elimination test, as standardized by Comroe and Fowler, has been used in normal subjects. The N2 difference, i.e. the difference in N2 concentration between Ve = 1250 and Ve = 750 ml, showed a tendency to increase with increasing volumes of inspired O2 and with increasing inspiratory flow rates. It decreased with increasing breath-holding time and was not consistently influenced by expiratory flow rate. The findings are compared with those of Fowler and of Shephard on normal subjects; different results were obtained, largely depending on different analytical procedures. These factors must be considered when evaluating results in patients.

Submitted on July 21, 1958




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