Journal of Applied Physiology
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J Appl Physiol 13: 491-492, 1958;
8750-7587/58 $5.00
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Effect of Acetazoleamide (Diamox) on Thyroid Function

J. L. Gabrilove 1, A. A. Alvarez 1, and L. J. Soffer 1

1 From the Endocrine Research Laboratory and Clinic of the Department of Medicine, and the Department of Chemistry, The Mount Sinai Hospital, New York City

The administration of acetazoleamide (Diamox), a potent sulfonamide carbonic anhydrase inhibitor, results in a decreased uptake of I131 by the thyroid. This observation raises the question of the possible role of carbonic anhydrase in thyroid function.

Submitted on May 8, 1958






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