Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 13: 411-416, 1958;
8750-7587/58 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, S. A.
Right arrow Articles by Priest, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, S. A.
Right arrow Articles by Priest, E. M.

Effect of Administration of Phenindione on Blood Levels of Prothrombin, Autoprothrombin I and Autoprothrombin II

Shirley A. Johnson 1, M. June Caldwell 1, and Edward McCall Priest 1

1 From the Department of Laboratories and Division of Cardiology, Henry Ford Hospital, Detroit, Michigan

Phenindione was administered to 14 patients in the Cardiology Division. Prothrombin, autoprothrombin I and autoprothrombin II determinations were carried out on plasma and serum samples drawn before administration of the drug, during and following administration. The prothrombin, autoprothrombin I and II all fell in concentration simultaneously. Prothrombin and autoprothrombin I recovered at the same rate, while autoprothrombin II returned to the original concentration much later. The response of the three components to administration of vitamin K1 was also observed.

Submitted on July 21, 1958






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online