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J Appl Physiol 13: 237-238, 1958;
8750-7587/58 $5.00
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Chlorpromazine Hypothermia in Rats

J. LeBlanc 1

1 From the Applied Physiology Branch, Directorate of Medical Research, U. S. Army Chemical Warfare Laboratories, Army Chemical Center, Maryland

The relatively small decrease in heat production and insignificant increase in heat loss for a given area which are observed after chlorpromazine (10 mg/kg) injection in rats cannot explain the marked hypothermia observed with this drug. It seems, however, that the increased surface area exposed to the environment as a result of postural changes, at a time when the animal has lost its heat regulating capacity, is a factor of importance in explaining the hypothermia caused by chlorpromazine in rats. The species difference in this hypothermic response between humans and rats is also discussed.

Submitted on March 31, 1958




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E. Epstein and K. Anna
Accidental hypothermia.
BMJ, March 25, 2006; 332(7543): 706 - 709.
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