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J Appl Physiol 13: 184-188, 1958;
8750-7587/58 $5.00
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Effect of Increased Carbon Dioxide Retention on Liver Function in the Dog

Edward L. Holmes 1 and Marion I. Barnhart 1

1 From the Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan

The removal of bromsulphalein dye from the blood stream of anesthetized dogs exposed to elevated CO2 tension was delayed. The range of increased BSP retention at 30 minutes was from 94 to 194%. Even when the tests were extended beyond the usual time, namely to 60 minutes, clearance of the dye was delayed. Anoxia was ruled out as a contributing factor since high levels of oxygen were maintained in all experiments. Preliminary exploration of possible mechanisms underlying the BSP retention was undertaken. There was no correlation between blood pH and the amount of BSP retained. Blood pressure determinations indicated that circulation was not altered appreciably during the test period.

Submitted on March 28, 1958






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