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J Appl Physiol 13: 179-183, 1958;
8750-7587/58 $5.00
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Respiratory Compensation to Metabolic Alkalosis in Dogs: Influence of High Oxygen Concentration

J. L. Reeves 1 and E. B. Brown JR. 1

1 From the Department of Physiology, University of Minnesota, Minneapolis, Minnesota

Dogs were made alkalotic either by intravenous administration of NaHCO3 or by gastric drainage. In every case some degree of respiratory compensation for the metabolic alkalosis was evident. In no case was compensation complete. The mean increase in CO2 tension during alkalosis was about a third that which would have been required to produce complete compensation. Breathing oxygen instead of air did not produce a further significant increase in compensation.

Submitted on March 14, 1958






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