Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 12: 334-338, 1958;
8750-7587/58 $5.00
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Inhibiting Effect of Norepinephrine on Gastric Secretion in Human Subjects

Anthony J. Leonsins 1 and William R. Waddell 1

1 From the Surgical Services, Massachusetts General Hospital, the Department of Surgery, Harvard Medical School, and the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Vasoconstriction produced by intravenous infusion of dilute norepinephrine solutions into human subjects inhibited gastric secretion during basal states and after stimulation by peptone broth, histamine and insulin hypoglycemia. The principal effect was reduction of the volume of gastric juice. In some instances the acidity and chloride concentration were higher during periods of low volume secretion produced by norepinephrine than during control periods.

Submitted on November 12, 1957






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