Journal of Applied Physiology
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J Appl Physiol 12: 262-268, 1958;
8750-7587/58 $5.00
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Pulmonary Surface Tension and the Mucus Lining of the Lungs: Some Theoretical Considerations

John A. Clements 1, Elwyn S. Brown 1, and Rudolph P. Johnson 1

1 From the Clinical Investigation Branch, Directorate of Medical Research, Army Chemical Center, Maryland

An attempt is made to clarify the dependence of static pressure-volume characteristics of the lung on internal surface forces. The theoretical development is based on two premises: a) the lung is lined with surface-denaturable mucus; b) alveolar sizes deviate significantly from the mean. The surface forces in a single unit are computed from the surface tension and changes in tension with area of a mucoprotein film. The effects of surface forces in the lung as a whole are obtained by summation, using the distribution of sizes. The major outlines of the pulmonary pressure-volume diagram are quantitatively deduced, including opening pressures, hysteresis and residual volumes. The role of surface compressibility in the structural stability of the lung is explored.

Submitted on August 12, 1957




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