Journal of Applied Physiology
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J Appl Physiol 12: 51-54, 1958;
8750-7587/58 $5.00
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Effect of a Mercurial Diuretic on the Excretion of ‘Free Water’ in Diabetes Insipidus

H. O. Heinemann 1 and E. L. Becker 1

1 From the Department of Physiology, New York University College of Medicine, New York City, and the Department of Medicine, Medical College of Virginia, Richmond, Virginia

The effect of Mercuhydrin on the ‘free water’ clearance was used to localize its site of action. In diabetes insipidus this diuretic increases the excretion of ‘free water.’ A similar effect attends the administration of mannitol and hypertonic sodium chloride solution. These results suggest that the increment in ‘free water’ clearance following the administration of these agents involves the same basic mechanism, i.e. increased presentation of reabsorbable solutes at the site of ‘free water’ formation.

Submitted on May 16, 1957






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