Journal of Applied Physiology
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J Appl Physiol 11: 450-454, 1957;
8750-7587/57 $5.00
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Thrombin Inhibition of the Lipoprotein Lipase System

Laurence O. Pilgeram 1 and Anthony T. Tu 1

1 From the Department of Biochemistry, Stanford University, Stanford, California

The blood coagulation enzyme, thrombin, has been found to act as a potent inhibitor of the lipoprotein lipase system. All other blood coagulation factors when tested individually were without inhibitory action. Analysis of our present knowledge of the physiological role of the lipoprotein lipase system suggests an atherogenic role for the thrombin inhibition phenomenon.

Submitted on June 21, 1957






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