Journal of Applied Physiology
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J Appl Physiol 11: 216-218, 1957;
8750-7587/57 $5.00
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Effect of a Tranquilizing Agent on Galvanic Skin Response

F. B. Benjamin 1, K. Ikai 1, and H. E. Clare 1

1 From the Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, and Aviation Medical Acceleration Laboratory, Naval Aviation Development Center, Johnsville, Pennsylvania

The effect of 10 mg of preclorperazine (Compazine, Smith, Kline and French) on the galvanic skin response was determined in a series of 36 double blind tests. As control, 10 mg of phenobarbital was given to simulate the slightly sedative side effects of the tranquilizing agent. A second control group received no drug. The results indicate the following effects of the tranquilizing agent: The basal galvanic skin resistance is increased and the galvanic skin response to pain is lowered. The variability of the base level is decreased, while the variability of the pain response is increased. This last observation might be due to differences in susceptibility to the drug. All other changes are of the same nature and are only slightly more pronounced than those observed in the phenobarbital group.

Submitted on March 7, 1957






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