Journal of Applied Physiology
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J Appl Physiol 11: 17-21, 1957;
8750-7587/57 $5.00
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Interaction of Serum Lipoproteins With Heparin and Phenol

Angelo Scanu 1, Lena A. Lewis 1, and Michael C. Schotz 1

1 From the Division of Research of The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute, Cleveland, Ohio

Addition of phenol to serum induces turbidity which appears to be due chiefly to the beta-lipoproteins. Serum from subjects who have received heparin injections shows decreased phenol turbidity, which appears to be due to formation of a fatty acid-lipoprotein complex, produced in connection with activation of the ‘clearing’ mechanism. Addition of heparin in vitro to mixtures of phenol and serum results in an increased turbidity. The isolated precipitate (by centrifugation) is similar to isolated betalipoprotein, in its ratio of cholesterol to phospholipid. The technique described may furnish a rapid, inexpensive method for determination of beta-lipoproteins in serum, which can be used clinically as a substitute for the expensive, time-consuming isolation by ultracentrifugation.

Submitted on March 15, 1957




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