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HIGHLIGHTED TOPIC
The Role of Clock Genes in Cardiometabolic Disease

Fat circadian biology

Pennington Biomedical Research Center, Baton Rouge, Louisiana

Submitted 29 January 2009 ; accepted in final form 15 May 2009

While adipose tissue has long been recognized for its major role in metabolism, it is now appreciated as an endocrine organ. A growing body of literature has emerged that identifies circadian mechanisms as a critical regulator of adipose tissue differentiation, metabolism, and adipokine secretory function in both health and disease. This concise review focuses on recent data from murine and human models that highlights the interplay between the core circadian regulatory proteins and adipose tissue in the context of energy, fat, and glucose metabolism. It will be important to integrate circadian mechanisms and networks into future descriptions of adipose tissue physiology.

adipose tissue; circadian; obesity; transcription factors