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Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans

¹School of Medicine, ; ²Division of Physiology, Department of Medicine, ; ³Pulmonary Imaging Laboratory, Department of Radiology, University of California, San Diego, La Jolla, California

Submitted 7 May 2009 ; accepted in final form 9 September 2009

Exercise presents a considerable stress to the pulmonary system and ventilation-perfusion (A/) heterogeneity increases with exercise, affecting the efficiency of gas exchange. In particular, prolonged heavy exercise and maximal exercise are known to increase A/ heterogeneity and these changes persist into recovery. We hypothesized that the spatial heterogeneity of pulmonary perfusion would be similarly elevated after prolonged exercise. To test this, athletic subjects (n = 6, O_2max = 61 ml· kg^–1·min^–1) with exercising A/ heterogeneity previously characterized by the multiple inert gas elimination technique (MIGET), performed 45 min of cycle exercise at 70% O_2max. MRI arterial spin labeling measures of pulmonary perfusion were acquired pre- and postexercise (at 20, 40, 60 min post) to quantify the spatial distribution in isogravitational (coronal) and gravitationally dependent (sagittal) planes. Regional proton density measurements allowed perfusion to be normalized for density and quantified in milliliters per minute per gram. Mean lung density did not change significantly in either plane after exercise (P = 0.19). Density-normalized perfusion increased in the sagittal plane postexercise (P = <0.01) but heterogeneity did not (all P 0.18), likely because of perfusion redistribution and vascular recruitment. Density-normalized perfusion was unchanged in the coronal plane postexercise (P = 0.66), however, perfusion heterogeneity was significantly increased as measured by the relative dispersion [RD, pre 0.62(0.07), post 0.82(0.21), P < 0.0001] and geometric standard deviation [GSD, pre 1.74(0.14), post 2.30(0.56), P < 0.005]. These changes in heterogeneity were related to the exercise-induced changes of the log standard deviation of the ventilation distribution, an MIGET index of A/ heterogeneity (RD R² = 0.68, P < 0.05, GSD, R² = 0.55, P = 0.09). These data are consistent with but not proof of interstitial pulmonary edema as the mechanism underlying exercise-induced increases in both spatial perfusion heterogeneity and A/ heterogeneity.

functional magnetic resonance imaging; ventilation-perfusion inequality; lung density