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Protein and carbohydrate supplementation after exercise increases plasma volume and albumin content in older and young men

Departments of ¹Sports Medical Sciences and ²Anesthesiology and Resuscitation, Shinshu University Graduate School of Medicine, Matsumoto; and ³Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co. Ltd., Kanzaki, Japan

Submitted 21 September 2008 ; accepted in final form 8 July 2009

This study examined whether increased plasma volume (PV) and albumin content (Alb_cont) in plasma for 23 h after exercise were attenuated in older subjects compared with in young adult subjects, and if this attenuation abated by supplementation with protein and carbohydrate (CHO) immediately after exercise. Eight moderately active older (68 yr) and 8 young (21 yr) men performed two trials: control (CNT) and Pro-CHO in which subjects consumed placebo (0.5 kcal, 0 g protein, 0.5 mg Na⁺ in 3.2 ml total fluid volume/kg body wt) or protein and CHO mixture (3.2 kcal, 0.18 g protein, 0.5 mg Na⁺ in 3.2 ml total fluid volume/kg body wt) supplementations, respectively, immediately after high-intensity interval exercise for 72 min [8 sets of 4 min at 70–80% peak oxygen consumption rate (O_2peak) intermitted by 5 min at 20% O_2peak]. PV, Alb_cont, and plasma globulin content (Glb_cont) were measured before exercise, at the end of exercise, every hour from the 1st to the 5th hour after exercise, and at the 23rd hour after exercise. From 12 h before the start to the end of experiment, food intake was controlled to the age-matched recommended dietary allowances. We found that during the first 4 h after exercise in CNT, Alb_cont recovered less in the older than the young group by 0.04 g/kg (P < 0.05), while it generally recovered more with Pro-CHO than CNT by 0.09 and 0.04 g/kg in the young and older group, respectively, accompanied by a greater increase in PV by 1 and 2 ml/kg, respectively, during the 23 h after exercise (P < 0.05). Glb_cont remained constant throughout the experiment in both trials for both age groups. Thus the attenuated responses of Alb_cont and PV after exercise in older subjects were restored by protein and CHO supplementation immediately after exercise, similarly to young subjects.

aging; blood volume; plasma protein

This article has been cited by other articles:

				K. Okazaki, T. Ichinose, H. Mitono, M. Chen, S. Masuki, H. Endoh, H. Hayase, T. Doi, and H. Nose Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men J Appl Physiol, September 1, 2009; 107(3): 725 - 733. [Abstract] [Full Text] [PDF]