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J Appl Physiol 107: 8-16, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.00343.2009
8750-7587/09 $8.00
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REVIEW

The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise

Matthew M. Robinson, Karyn L. Hamilton, and Benjamin F. Miller

Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado

Submitted 1 April 2009 ; accepted in final form 6 May 2009

ABSTRACT

The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations.

β-adrenergic blockers; nonsteroidal anti-inflammatory drug; statins; mitochondrial biogenesis; chronic disease


Address for reprint requests and other correspondence: B. F. Miller, Dept. of Health and Exercise Science, Colorado State Univ., 200 Moby B Complex, Fort Collins, CO 80523-1582 (e-mail: bfmiller{at}cahs.colostate.edu)






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