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J Appl Physiol 107: 336-345, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.91012.2008
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HIGHLIGHTED TOPIC
The Physiology and Pathophysiology of the Hyperbaric and Diving Environments

Arterial and pulmonary arterial hemodynamics and oxygen delivery/extraction in normal humans exposed to hyperbaric air and oxygen

Lindell K. Weaver,1,2,3 Steve Howe,2 Gregory L. Snow,4 and Kayla Deru2

1Pulmonary/Critical Care Medicine and 2Hyperbaric Medicine, LDS Hospital, Salt Lake City; 3Department of Medicine, University of Utah School of Medicine, Salt Lake City; and 4Statistical Data Center, LDS Hospital, Salt Lake City, Utah

Submitted 2 August 2008 ; accepted in final form 23 April 2009

Divers and hyperbaric chamber attendants breathe hyperbaric air routinely. Hyperbaric oxygen (HBO2) is used therapeutically frequently. Although much is understood about the hemodynamic physiology and gas exchange effects during hyperbaric air and HBO2 exposure, arterial and pulmonary arterial (PA) catheter data, including blood gas values during hyperbaric air and HBO2 exposure of normal humans, have not been reported. We exposed 10 healthy volunteers instrumented with arterial and PA catheters to air at 0.85, 3.0, 2.5, 2.0, 1.3 (decompression stop), 1.12 (decompression stop), and 0.85 atm abs (our altitude) and then at identical pressures breathing O2 followed by atmospheric pressure air while we measured arterial and PA pressures (PAP), cardiac output (Q), and blood gas measurements from both arterial and PA catheters. Although hemodynamic changes occurred during exposure to both hyperbaric air and HBO2, we observed a greater magnitude of change under HBO2 conditions: heart rate changes ranged from –9 to –19% (air to O2), respiratory rate from –12 to –17%, Q from –7 to –18%, PAP from –18 to –19%, pulmonary vascular resistance from –38 to –48%, and right-to-left shunt fraction from –87 to –107%. Mixed venous CO2 fell 8% from baseline during HBO2 despite mixed venous O2 tensions of several hundred Torr. The stroke volume, O2 delivery, and O2 consumption did not change across exposures. The arterial and mixed venous partial pressures of O2 and contents were elevated, as predicted. O2 extraction increased 37% during HBO2.

hyperbaric oxygen; pulmonary arterial catheter; cardiac output; oxygen extraction


Address for reprint requests and other correspondence: L. K. Weaver, Hyperbaric Medicine, LDS Hospital, Eighth Ave. and C St., Salt Lake City, UT 84143 (e-mail: lindell.weaver{at}imail.org)






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