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This Article Full Text Full Text (PDF) All Versions of this Article: 107/1/261    most recent 00249.2009v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Almeida, P. W. M. Articles by Pussieldi, G. A. PubMed PubMed Citation Articles by Almeida, P. W. M. Articles by Pussieldi, G. A.

Swim training suppresses tumor growth in mice

¹Department of Environmental, Biological and Health Sciences, University Center of Belo Horizonte, Belo Horizonte; Departments of ²Physiology and Biophysics, ³Morphology, ⁴Biochemistry and Immunology, and ⁵Pathology, Institute of Biological Sciences, and ⁶Exercise Physiology Laboratory, Federal University of Minas Gerais, Belo Horizonte, Brazil; ⁷Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim; and ⁸Department of Cardiology, St. Olavs Hospital, Trondheim, Norway

Submitted 9 March 2009 ; accepted in final form 26 May 2009

The present study was designed to determine the effects of physical training on the development of cancer induced by the injection of Ehrlich tumor cells in mice. Male Swiss mice were subjected to a swim training protocol (5 days/wk for 6 wk, 1 h at 50% of maximal capacity-trained groups) or remained sedentary in their cages (sedentary groups). The inoculation of Ehrlich tumor cells was performed at the end of the fourth week, and animals were killed after 6 wk of training. Heart and solid tumor weights were recorded, and tumor volumes were calculated. Portions of the tumors were used for the evaluation of macrophages and neutrophil accumulation or fixed in neutral 10% buffered formalin for histological analysis. The tumor volume and weight were, respectively, 270% and 280% greater in sedentary mice than in trained mice. Macrophage infiltration in the tumor tissue was significantly lower in trained mice (0.65 ± 0.16 vs. 1.78 ± 0.43 macrophages x 10³ in the sedentary group). Moreover, neutrophil accumulation in tumors was slightly reduced after exercise training, and the amount of tumor cells was reduced in trained mice. Exercise capacity was substantially increased in trained mice, as determined by a 440% increase in the exercise time at 50% of maximal capacity. In summary, swim training retarded the development of Ehrlich tumors in mice, accompanied by a reduction in macrophage infiltration and neutrophil accumulation. These findings provide conceptual support for clinical observations that controlled physical activities may be a therapeutically important approach to preventing cancer progression and may improve the outcome of cancer treatment.

cancer; macrophage; neutrophil; physical training