Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 106: 1553-1563, 2009. First published February 26, 2009; doi:10.1152/japplphysiol.91550.2008
8750-7587/09 $8.00
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Prior moderate and heavy exercise accelerate oxygen uptake and cardiac output kinetics in endurance athletes

Azmy Faisal, Keith R. Beavers, Andrew D. Robertson, and Richard L. Hughson

Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada

Submitted 30 November 2008 ; accepted in final form 25 February 2009

Cardiorespiratory interactions at the onset of dynamic cycling exercise are modified by warm-up exercises. We tested the hypotheses that oxygen uptake (VO2) and cardiac output (Q) kinetics would be accelerated at the onset of heavy and moderate cycling exercise by warm-up. Nine male endurance athletes (peak VO2: 60.5 ± 3.2 ml·min–1·kg–1) performed multiple rides of two different 36-min cycling protocols, involving 6-min bouts at moderate and heavy intensities. Breath-by-breath VO2 and beat-by-beat stroke volume (SV) and Q, estimated by Modelflow from the finger pulse, were measured simultaneously with kinetics quantified from the phase II time constant ({tau}2). One novel finding was that both moderate (M) and heavy (H) warm-up bouts accelerated phase II VO2 kinetics during a subsequent bout of heavy exercise ({tau}2: after M = 22.5 ± 2.7 s, after H = 22.1 ± 2.9 vs. 26.2 ± 3.2 s; P < 0.01). Q kinetics in heavy exercise were accelerated by both warm-up intensities ({tau}2: M = 22.0 ± 4.1 s, H = 23.8 ± 5.6 s vs. 27.4 ± 7.2 s; P < 0.05). During moderate exercise, prior heavy-intensity warm-up (one or two bouts) accelerated VO2 kinetics and elevated Q at exercise onset, with no changes in Q kinetics. A second novel finding was a significant overshoot in the estimate of SV from Modelflow in the first minutes of each moderate and heavy exercise bout. These findings suggest that the acceleration of VO2 kinetics during heavy exercise was enabled by the acceleration of Q kinetics, and that rapid increases in Q at the onset of moderate and heavy exercise might result, in part, from an overshoot of SV.

gas exchange; warm-up exercise; arterial-venous oxygen content difference; Finometer Modelflow; acetylene rebreathing



Address for reprint requests and other correspondence: R. L. Hughson, Faculty of Applied Health Sciences, Univ. of Waterloo, Waterloo, ON N2L3G1, Canada (e-mail: hughson{at}healthy.uwaterloo.ca)




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S. Perrey, M. Burnley, G. P. Millet, F. Borrani, A. M. Jones, D. C. Poole, S. W. Copp, D. M. Hirai, P. Gimenez, T. Busso, et al.
Comments on point: counterpoint: the kinetics of oxygen uptake during muscular exercise do/do not manifest time-delayed phase. Modeling concerns.
J Appl Physiol, November 1, 2009; 107(5): 1669 - 1670.
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