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HIGHLIGHTED TOPIC
Regulation of Protein Metabolism in Exercise and Recovery

Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains

¹LIKES Research Center for Sport and Heath Sciences, and ²Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyväskylä, Finland

Submitted 16 May 2008 ; accepted in final form 10 January 2009

Eccentric exercise induced by electrostimulation increases mRNA expression of titin-complex proteins in rodent skeletal muscle. In this study, mRNA expression of titin, muscle LIM protein (MLP), cardiac ankyrin repeat protein (CARP), ankyrin repeat domain protein 2 (Ankrd2), diabetes-related ankyrin repeat protein (DARP), and calcium-activated proteinases, calpains, were investigated in human skeletal muscle after fatiguing jumping exercise. Fatiguing jumping exercise did not change mRNA expression of titin, DARP, calpain 1, or calpain 3. MLP, Ankrd2 and calpain 2 mRNA levels were increased 2 days postexercise. CARP mRNA level was already elevated 30 min and remained elevated 2 days postexercise. Increased mRNA expression of MLP, CARP, and Ankrd2, observed for the first time in human skeletal muscle, may be part of the signaling activated by physical exercise. The rapid increase in the level of CARP mRNA nominates CARP as one of the first genes to respond to exercise. The increase in the mRNA level of calpain 2 suggests its involvement in myofiber remodeling after strenuous jumping exercise.

muscle LIM protein; muscle ankyrin repeat protein; calpain; stretch-shortening cycle

This article has been cited by other articles:

				R. M. Murphy and G. D. Lamb Calpain-3 is activated following eccentric exercise J Appl Physiol, June 1, 2009; 106(6): 2068 - 2068. [Full Text] [PDF]

				M. Lehti, R. Kivela, P. Komi, J. Komulainen, H. Kainulainen, and H. Kyrolainen Reply to Murphy and Lamb J Appl Physiol, June 1, 2009; 106(6): 2069 - 2069. [Full Text] [PDF]