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REVIEW

HIGHLIGHTED TOPIC
Regulation of Protein Metabolism in Exercise and Recovery

Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals

Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky

Submitted 10 October 2008 ; accepted in final form 21 November 2008

ABSTRACT

Growth and maintenance of skeletal muscle mass is critical for long-term health and quality of life. Skeletal muscle is a highly adaptable tissue with well-known sensitivities to environmental cues such as growth factors, cytokines, nutrients, and mechanical loading. All of these factors act at the level of the cell and signal through pathways that lead to changes in phenotype through multiple mechanisms. In this review, we discuss the animal and cell culture models used and the signaling mechanisms identified in understanding regulation of protein synthesis in response to mechanical loading/resistance exercise. Particular emphasis has been placed on 1) alterations in mechanical loading and regulation of protein synthesis in both in vivo animal studies and in vitro cell culture studies and 2) upstream mediators regulating mammalian target of rapamycin signaling and protein synthesis during skeletal muscle hypertrophy.

mechanical stretch; REDD2; overload; IGF-1; amino acids

This article has been cited by other articles:

				B. B. Rasmussen and E. A. Richter The balancing act between the cellular processes of protein synthesis and breakdown: exercise as a model to understand the molecular mechanisms regulating muscle mass J Appl Physiol, April 1, 2009; 106(4): 1365 - 1366. [Full Text] [PDF]