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Right coronary artery becomes stiffer with increase in elastin and collagen in right ventricular hypertrophy

¹Department of Biomedical Engineering, Surgery, Cellular and Integrative Physiology, Indiana University Purdue University, Indianapolis, Indiana; and ²Department of Biomedical Engineering, University of California, Irvine, California

Submitted 29 September 2008 ; accepted in final form 26 January 2009

Changes in blood flow influence the structure, function, mechanical properties, and remodeling of arteries. The objective of the present study was to investigate the role of increased blood flow on the biaxial incremental elastic moduli of the porcine right coronary artery (RCA) and to determine the microstructural basis for the changes in moduli. We hypothesized that an increase in RCA flow will lead to increased stiffness in conjunction with remodeling of elastin and collagen in the vessel wall. The control and experimental groups consisted of five RCA vessels each. The RCA of the experimental group was exposed to 4 wk of flow-overload in right ventricular hypertrophy induced by pulmonary artery banding. Stress-strain relationships were determined and the incremental elastic moduli were derived in the circumferential, axial, and cross directions. The results show a significant increase in the elastic moduli in the circumferential (262.7 ± 15.7 vs. 120.2 ± 12.4 kPa; P < 0.001), axial (177.8 ± 25.5 vs. 100.3 ± 11.9 kPa; P = 0.025), and cross directions (104.8 ± 8.2 vs. 68.2 ± 8.6 kPa; P = 0.016) of the experimental RCA compared with controls. Multiphoton microscopy was used to assess the changes in elastin and collagen content in the media and adventitia of the vessel wall. We found a significant increase in elastin and collagen area fraction particularly in the adventitial layer. These data suggest stiffening of the vessel wall as a result of increased elastin and more predominantly collagen.

stress; strain; wall shear stress; constitutive equation