Journal of Applied Physiology Information on EB 2010
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J Appl Physiol 106: 1223-1226, 2009. First published January 22, 2009; doi:10.1152/japplphysiol.91192.2008
8750-7587/09 $8.00
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Laryngeal constriction during hypoxic gasping and its role in improving autoresuscitation in two mouse strains

Z. Song, K. A. Harris, and B. T. Thach

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri

Submitted 5 September 2008 ; accepted in final form 22 January 2009

Laryngeal closure following hypoxic gasps has been documented, but its efficacy in improving autoresuscitation capacity is unknown. We studied SWR/J mice who normally cannot autoresuscitate and the C57/BLJ strain who can. We evaluated the effects of elevated end-inspiratory lung volume immediately following a gasp. We compared upper airway-intact mice with tracheostomized mice in which the vocal cords are bypassed. We used the techniques of repeated autoresuscitate trials to test autoresuscitation capability. Both SWR/J and C57/BLJ mice could maintain elevated lung volume immediately after a gasp (breath holding). Such breath holding increased autoresuscitation ability in C57/BLJ mice but did not in SWR/J mice. In SWR/J mice, the duration of the breath holds was less than that in the C57/BLJ mice. These findings indicate that gasp-associated breath holding improves autoresuscitation capability during repeated autoresuscitation trials. Also, they show that SWR/J mice have a deficiency in central nervous system mechanisms regulating glottic closure during hypoxic gasping.

breath holding; control of respiration; SWR/J mice; C57/BLJ mice


Address for reprint requests and other correspondence: B. T. Thach, Washington Univ. School of Medicine, 660 S. Euclid, Campsus Box 8208, St. Louis, MO 63110 (e-mail: Thach{at}kids.wustl.edu)






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