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REVIEW

HIGHLIGHTED TOPIC
The Physiology and Pathophysiology of the Hyperbaric and Diving Environments

Oxidative stress is fundamental to hyperbaric oxygen therapy

Institute for Environmental Medicine and Department of Emergency Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

Submitted 1 August 2008 ; accepted in final form 1 October 2008

ABSTRACT

The goal of this review is to outline advances addressing the role that reactive species of oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will be organized around major categories of problems or processes where controlled clinical trials have demonstrated clinical efficacy for hyperbaric oxygen therapy. Reactive species are now recognized to play a major role in cell signal transduction cascades, and the discussion will focus on how hyperbaric oxygen acts through these pathways to mediate wound healing and ameliorate postischemic and inflammatory injuries.

wound healing; hypoxia-inducible factor; CD34; integrins; heat shock proteins

This article has been cited by other articles:

				D. P. D'Agostino, D. G. Colomb Jr., and J. B. Dean Effects of hyperbaric gases on membrane nanostructure and function in neurons J Appl Physiol, March 1, 2009; 106(3): 996 - 1003. [Abstract] [Full Text] [PDF]

				D. R. Pendergast and C. E. G. Lundgren The physiology and pathophysiology of the hyperbaric and diving environments J Appl Physiol, January 1, 2009; 106(1): 274 - 275. [Full Text] [PDF]