HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 106/1/326    most recent 91353.2008v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Erusalimsky, J. D. Search for Related Content PubMed PubMed Citation Articles by Erusalimsky, J. D.

REVIEW

HIGHLIGHTED TOPIC
Physiology of the Aging Vasculature

Vascular endothelial senescence: from mechanisms to pathophysiology

Cardiff School of Health Sciences, University of Wales Institute, Cardiff, United Kingdom

Submitted 10 October 2008 ; accepted in final form 20 November 2008

ABSTRACT

Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases.

endothelium; oxidative stress; telomere