Journal of Applied Physiology
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J Appl Physiol 105: 1741-1745, 2008. First published October 9, 2008; doi:10.1152/japplphysiol.90442.2008
8750-7587/08 $8.00
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Plasma NT-proBNP increases in response to LPS administration in healthy men

Greisa Vila,1 Michael Resl,1 David Stelzeneder,1 Joachim Struck,2 Christina Maier,1 Michaela Riedl,1 Martin Hülsmann,3 Richard Pacher,3 Anton Luger,1 and Martin Clodi1

1Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Austria; 2Research Department, BRAHMS, Biotechnology Centre, Hennigsdorf, Germany; and 3Department of Medicine II, Division of Cardiology, Medical University of Vienna, Austria

Submitted 24 March 2008 ; accepted in final form 1 October 2008

Circulating levels of B-type natriuretic peptide (BNP) and NH2-terminal-proBNP (NT-proBNP) increase in response to volume overload and help in the differential diagnosis of acute heart failure. Elevated plasma BNP levels are observed also in sepsis and do not always correspond to left ventricular dysfunction. Here, we investigated plasma NT-proBNP fluctuations in response to human bacterial endotoxinemia, an experimental model of systemic infection and inflammation. Escherichia coli endotoxin (LPS) (2 ng/kg) was administered to 10 healthy volunteers in a randomized, placebo-controlled, cross-over design. Plasma NT-proBNP, C-reactive protein (CRP), COOH terminal pro-endothelin-1 (CT-proET-1), and midregional-pro-adrenomedullin (MR-proADM) were measured at hourly intervals for 6 h. LPS administration induced a continuous increase in plasma NT-proBNP that reached peak values after 6 h (40.7 ± 7.9 vs. 16.1 ± 3.2 pg/ml in placebo days, mean ± SE; P = 0.023). The profile of changes in NT-proBNP correlated to changes in body temperature (P < 0.001), heart rate (P = 0.005), CRP (P < 0.001), and CT-proET-1 (P = 0.008), but not to blood pressure values. Our results demonstrate that plasma NT-proBNP increases in a model of systemic infection/inflammation in healthy men with normal heart function. This finding emphasizes the necessity to consider concomitant infections when interpreting elevated circulating NT-proBNP concentrations.

B-type natriuretic peptide; C-reactive protein; bacterial endotoxin; infection; inflammation; human


Address for reprint requests and other correspondence: M. Clodi, Dept. of Medicine III, Medical Univ. of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria (e-mail: martin.clodi{at}meduniwien.ac.at)






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