Journal of Applied Physiology
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J Appl Physiol 104: 1801-1808, 2008. First published April 17, 2008; doi:10.1152/japplphysiol.00057.2008
8750-7587/08 $8.00
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Postnatal changes in the expression of serotonin 2A receptors in various brain stem nuclei of the rat

Qiuli Liu and Margaret T. T. Wong-Riley

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin

Submitted 18 January 2008 ; accepted in final form 14 April 2008

Previously, we reported a critical period [around postnatal day (P) 12–13 in the rat] in respiratory network development when distinct neurochemical, metabolic, and physiological changes occur. Since serotonin 2A (5-HT2A) receptors play an important role in respiratory modulation, we hypothesized that they may undergo developmental adjustments during the critical period. Semi-quantitative immunohistochemical analyses were conducted in labeled neurons in a number of brain stem nuclei with or without known respiratory functions from P2 to P21 in rats. Our data indicate that the expressions of 5-HT2A receptors in neurons of the pre-Bötzinger complex, the nucleus ambiguus, and the hypoglossal nucleus were maintained within a relatively narrow range between P2 and P21, with a dip at P3–P4 and a significant reduction only at P12. This change was not observed in the nonrespiratory cuneate nucleus. These results suggest that reduced expressions of 5-HT2A receptors at P12 contributes to neurochemical imbalance within brain stem respiratory nuclei at that time and may be involved in decreased hypoxic ventilatory response at this critical period of development.

development; hypoglossal nucleus; nucleus ambiguus; pre-Bötzinger complex; respiratory nuclei


Address for reprint requests and other correspondence: M. T. T. Wong-Riley, Dept. of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 (e-mail: mwr{at}mcw.edu)






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