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J Appl Physiol 103: 2049-2056, 2007. First published September 20, 2007; doi:10.1152/japplphysiol.00627.2007
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Spatial heterogeneity of quadriceps muscle deoxygenation kinetics during cycle exercise

Shunsaku Koga,1 David C. Poole,2 Leonard F. Ferreira,2 Brian J. Whipp,3 Narihiko Kondo,4 Tadashi Saitoh,1 Etsuko Ohmae,5 and Thomas J. Barstow2

1Applied Physiology Laboratory, Kobe Design University, Kobe, Japan; 3University of Leeds, Leeds, United Kingdom; 4Kobe University, Kobe, Japan; 5Hamamatsu Photonics K. K., Hamakita, Japan; and 2Department of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan, Kansas

Submitted 12 June 2007 ; accepted in final form 19 September 2007

To test the hypothesis that, during exercise, substantial heterogeneity of muscle hemoglobin and myoglobin deoxygenation [deoxy(Hb + Mb)] dynamics exists and to determine whether such heterogeneity is associated with the speed of pulmonary O2 uptake (pVO2) kinetics, we adapted multi-optical fibers near-infrared spectroscopy (NIRS) to characterize the spatial distribution of muscle deoxygenation kinetics at exercise onset. Seven subjects performed cycle exercise transitions from unloaded to moderate [<gas exchange threshold (GET)] and heavy (>GET) work rates and the relative changes in deoxy(Hb + Mb), at 10 sites in the quadriceps, were sampled by NIRS. At exercise onset, the time delays in muscle deoxy(Hb + Mb) were spatially inhomogeneous [intersite coefficient of variation (CV), 3~56% for <GET, 2~21% for >GET]. The primary component kinetics (time constant) of muscle deoxy(Hb + Mb) reflecting increased O2 extraction were also spatially inhomogeneous (intersite CV, 6~48% for <GET, 7~47% for >GET) and faster (P < 0.05) than those of phase 2 pVO2. However, the degree of dynamic intersite heterogeneity in muscle deoxygenation did not correlate significantly with phase 2 pVO2 kinetics. In conclusion, the dynamics of quadriceps microvascular oxygenation demonstrates substantial spatial heterogeneity that must arise from disparities in the relative kinetics of VO2 and O2 delivery increase across the regions sampled.

near-infrared spectroscopy; oxygen uptake kinetics; muscle oxygen delivery; muscle oxygen utilization


Address for reprint requests and other correspondence: S. Koga, Applied Physiology Laboratory, Kobe Design Univ., 8-1-1 Gakuennishi-machi, Nishi-ku, Kobe, 651-2196, Japan (e-mail: s-koga{at}kobe-du.ac.jp)




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