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This Article Full Text Full Text (PDF) All Versions of this Article: 103/5/1628    most recent 00320.2007v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chung, L. H. Articles by Kent-Braun, J. A. Search for Related Content PubMed PubMed Citation Articles by Chung, L. H. Articles by Kent-Braun, J. A.

Age-related resistance to skeletal muscle fatigue is preserved during ischemia

Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts

Submitted 21 March 2007 ; accepted in final form 7 August 2007

During voluntary contractions, the skeletal muscle of healthy older adults often fatigues less than that of young adults, a result that has been explained by relatively greater reliance on muscle oxidative metabolism in the elderly. Our aim was to investigate whether this age-related fatigue resistance was eliminated when oxidative metabolism was minimized via ischemia induced by cuff (220 mmHg). We hypothesized that 1) older men (n = 12) would fatigue less than young men (n = 12) during free-flow (FF) contractions; 2) both groups would fatigue similarly during ischemia; and 3) reperfusion would reestablish the fatigue resistance of the old. Subjects performed 6 min of intermittent, maximal voluntary isometric contractions of the ankle dorsiflexors under FF and ischemia-reperfusion (IR) conditions. Ischemia was maintained for the first 3 min of contractions, followed by rapid cuff deflation and reperfusion for 3 additional minutes of contractions. Central activation, peripheral activation, and muscle contractile properties were measured at 3 and 6 min of contractions. Older men fatigued less than young men during FF (P 0.02), ischemia (P < 0.001), and reperfusion (P < 0.001). During FF, activation and contractile properties changed similarly across age groups. At the end of ischemia, central (P = 0.02) and peripheral (P 0.03) activation declined more in the young, with no effect of age on the changes in contractile properties. Thus age-related fatigue resistance was evident during FF and IR, indicating that differences in blood flow and oxidative metabolism do not explain the fatigue resistance of old age.

central activation; peripheral activation; contractile properties; muscle strength; reperfusion; isometric