Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 103: 1536-1542, 2007. First published August 9, 2007; doi:10.1152/japplphysiol.00575.2007
8750-7587/07 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
103/5/1536    most recent
00575.2007v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mortensen, O. H.
Right arrow Articles by Pedersen, B. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mortensen, O. H.
Right arrow Articles by Pedersen, B. K.

PGC-1β is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family

Ole Hartvig Mortensen,1,2 Peter Plomgaard,1,2 Christian P. Fischer,1,2 Anne K. Hansen,1,2 Henriette Pilegaard,2,3 and Bente Klarlund Pedersen1,2

1Centre of Inflammation and Metabolism at Department of Infectious Diseases and 2Copenhagen Muscle Research Centre, Rigshospitalet, and 3Centre of Inflammation and Metabolism, Institute of Molecular Biology and Physiology, August Krogh Institute, University of Copenhagen, Copenhagen, Denmark

Submitted 28 May 2007 ; accepted in final form 6 August 2007

We hypothesized that the peroxisome proliferator-activated receptor-{gamma} coactivator-1 (PGC-1) family of transcriptional coactivators (PGC-1{alpha}, PGC-1β, and PRC) is differentially regulated by training once daily vs. training twice daily every second day and that this difference might be observed in the acute response to endurance exercise. Furthermore, we hypothesized that expression levels of the PGC-1 family differ with muscular fiber-type composition. Thus, before and after 10 wk of knee extensor endurance training, training one leg once daily and the other leg twice daily every second day, keeping the total amount of training for the legs equal, skeletal muscle mRNA expression levels of PGC-1{alpha}, PGC-1β, and PRC were determined in young healthy men (n = 7) in response to 3 h of acute exercise. No significant difference was found between the two legs, suggesting that regulation of the PGC-1 family is independent of training protocol. Training decreased PGC-1β in both legs, whereas PGC-1{alpha} was increased, but not significantly, in the leg training once daily. PRC did not change with training. Both PGC-1{alpha} and PRC were increased by acute exercise both before and after endurance training, whereas PGC-1β did not change. The mRNA levels of the PGC-1 family were examined in different types of human skeletal muscle (triceps, soleus, and vastus lateralis; n = 7). Only the expression level of PGC-1β differed and correlated inversely with percentage of type I fibers. In conclusion, there was no difference between training protocols on the acute exercise and training response of the PGC-1 family. However, training caused a decrease in PGC-1β mRNA levels.

peroxisome proliferator-activated receptor-{gamma} coactivator-1; peroxisome proliferator-activated receptor-{gamma} coactivator-1β; peroxisome proliferator-activated receptor-{gamma} coactivator-1-related cofactor; adaptation; glycogen


Address for reprint requests and other correspondence: O. H. Mortensen, Centre of Inflammation and Metabolism, Rigshospitalet 7641, Blegdamsvej 9, DK-2100 Copenhagen, Denmark (e-mail: ole{at}hartvig.org)




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. Wenz, F. Diaz, D. Hernandez, and C. T. Moraes
Endurance exercise is protective for mice with mitochondrial myopathy
J Appl Physiol, May 1, 2009; 106(5): 1712 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. K. Yeo, C. D. Paton, A. P. Garnham, L. M. Burke, A. L. Carey, and J. A. Hawley
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
J Appl Physiol, November 1, 2008; 105(5): 1462 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. K. Yeo, S. J. Lessard, Z.-P. Chen, A. P. Garnham, L. M. Burke, D. A. Rivas, B. E. Kemp, and J. A. Hawley
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
J Appl Physiol, November 1, 2008; 105(5): 1519 - 1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. S. Mathai, A. Bonen, C. R. Benton, D. L. Robinson, and T. E. Graham
Rapid exercise-induced changes in PGC-1{alpha} mRNA and protein in human skeletal muscle
J Appl Physiol, October 1, 2008; 105(4): 1098 - 1105.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.