Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 103: 1007-1011, 2007. First published July 12, 2007; doi:10.1152/japplphysiol.00147.2007
8750-7587/07 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
103/3/1007    most recent
00147.2007v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sloan, R. P.
Right arrow Articles by Flood, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sloan, R. P.
Right arrow Articles by Flood, P. D.

Aerobic exercise attenuates inducible TNF production in humans

Richard P. Sloan,1,2 Peter A. Shapiro,3 Ronald E. DeMeersman,4 Paula S. McKinley,1,2 Kevin J. Tracey,5 Iordan Slavov,1,2 Yixin Fang,1,2 and Pamela D. Flood6

1Division of Behavioral Medicine, Department of Psychiatry, Columbia University, 2New York State Psychiatric Institute, 3Division of Consultation Liaison Psychiatry, Department of Psychiatry, Columbia University Medical Center, 4Department of Rehabilitation Medicine, Columbia University Medical Center, 5The Feinstein Institute for Medical Research at North Shore-LIJ Health System, and 6Department of Anesthesiology, Columbia University Medical Center, New York, New York

Submitted 5 February 2007 ; accepted in final form 9 July 2007

Aerobic exercise reduces coronary heart disease risk, but the mechanisms of this protection are not fully understood. Atherosclerosis is an inflammatory disease mediated by monocyte-derived macrophages, which accumulate in arterial plaques and become activated to release factors, including cytokines, that cause damage. Here we studied the effects of aerobic training on monocyte production of tumor necrosis factor (TNF) in whole blood ex vivo. Healthy young sedentary adults (n = 61, age 20–45 yr) were randomized to a moderate- (M) or a high- (H) intensity 12-wk training program. Whole blood was extracted before and after training, and then it was stimulated by addition of lipopolysaccharide (LPS); inducible TNF was measured in the plasma. Data were analyzed according to intention to treat principles using a random-effect model to determine the impact of training group on maximal aerobic capacity and LPS-stimulated TNF after correcting for covariates. Analyses revealed improvement in aerobic capacity in both the H (9%) and the M (7%) groups. However, aerobic training led to significant (P < 0.001) decreases in TNF release only in the H group. These data suggest that in healthy young adults, a 12-wk high-intensity aerobic training program downregulates blood monocyte production of stimulated cytokine release.

exercise; inflammation; laboratory study


Address for reprint requests and other correspondence: R. P. Sloan, Columbia Univ., 1150 St. Nicholas Ave., Suite 121, New York, NY 10032 (e-mail: rps7{at}columbia.edu)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.