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Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats

M. L. Batista, Jr.,^1,4 R. V. T. Santos,^1,3 E. M. Oliveira,² M. C. L. Seelaender,¹ and L. F. B. P. Costa Rosa

¹Molecular Biology of the Cell Group, Institute of Biomedical Sciences, and ²Department of Biodynamic of the Human Body Movement, School of Sport and Physical Education, University of São Paulo; ³Research Center of Psychobiology and Sports, Paulista School of Medicine, Federal University of São Paulo; and ⁴School of Physical Education, University of Mogi das Cruzes, São Paulo, Brazil

Submitted 7 August 2006 ; accepted in final form 18 January 2007

Congestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (Ms) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor- (TNF-) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13–20 m/min) for 60 min/day, 5 days/wk, for 8–10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml·kg^–1·min^–1), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. The resident and total cell number, the chemotaxis index, and the production of TNF- stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M function and induces beneficial metabolic effects in rats with post-MI CHF.

pro-inflammatory cytokines; migration; chemotaxis index; phagocytic capacity; exercise adaptation; myocardial infarction

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