HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 102/2/665    most recent 00521.2006v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Loganathan, R. Articles by Smirnova, I. V. Search for Related Content PubMed PubMed Citation Articles by Loganathan, R. Articles by Smirnova, I. V.

Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses

Departments of ¹Physical Therapy and Rehabilitation Science and ²Molecular and Integrative Physiology, and ³Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City; and ⁴Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas

Submitted 5 May 2006 ; accepted in final form 25 October 2006

Diabetic cardiomyopathy is a distinct myocardial complication of the catabolic state of untreated insulin-dependent diabetes mellitus in the streptozotocin-induced diabetic rat. Exercise training has long been utilized as an effective adjunct to pharmacotherapy in the management of the diabetic heart. However, the in vivo functional benefit(s) of the training programs on cardiac cycle events in diabetes are poorly understood. In this study, we used three groups of Sprague-Dawley rats (sedentary control, sedentary diabetic, and exercised diabetic) to assess the effects of endurance training on the left ventricular (LV) cardiac cycle events in diabetes. At the end of 9 wk of exercise training, noninvasive cardiac functional evaluation was performed by using high-resolution magnetic resonance imaging (9.4 T). An ECG-gated cine imaging protocol was used to capture the LV cardiac cycle events through 10 equally incremented phases. The cardiac cycle phase volumetric profiles showed favorable functional changes in exercised diabetic group, including a prevention of decreased end-diastolic volume and attenuation of increased end-systolic volume that accompanies sedentary diabetes. The defects in LV systolic flow velocity, acceleration, and jerk associated with sedentary diabetes were restored toward control levels in the trained diabetic animals. This magnetic resonance imaging study confirms the prevailing evidence from earlier in vitro and in vivo invasive procedures that exercise training benefits cardiac function in this model of diabetic cardiomyopathy despite the extreme catabolic state of the animals.

cardiac cycle; diabetic cardiomyopathy; left ventricle; magnetic resonance imaging

This article has been cited by other articles:

				K. R. Bidasee, H. Zheng, C.-H. Shao, S. K. Parbhu, G. J. Rozanski, and K. P. Patel Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of {beta}-adrenoceptors J Appl Physiol, September 1, 2008; 105(3): 907 - 914. [Abstract] [Full Text] [PDF]