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Obesity and asthma: lessons from animal models

Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts

Epidemiological data indicate that obesity is a risk factor for asthma. These data are supported by observations in several murine models of obesity. Ob/ob, db/db, and Cpe^fat mice each exhibit innate airway hyperresponsiveness, a characteristic feature of asthma. These mice also respond more vigorously to common asthma triggers, including ozone. Here we discuss the implications of these data with respect to several mechanisms proposed to explain the relationship between obesity and asthma: 1) common etiologies; 2) comorbidities; 3) mechanical factors; and 4) adipokines. We focus on the role of adipokines, especially TNF-, IL-6, leptin, and adiponectin. Understanding the mechanistic basis for the relationship between obesity and asthma may lead to novel therapeutic strategies for treatment of the obese asthmatic subject.

mice; leptin; adiponectin; tumor necrosis factor-; interleukin-6; adipokines

This article has been cited by other articles:

				J. E. Lang, E. S. Williams, J. P. Mizgerd, and S. A. Shore Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6 Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L1013 - L1020. [Abstract] [Full Text] [PDF]

				S. E. Alexeeff, A. A. Litonjua, H. Suh, D. Sparrow, P. S. Vokonas, and J. Schwartz Ozone Exposure and Lung Function: Effect Modified by Obesity and Airways Hyperresponsiveness in the VA Normative Aging Study Chest, December 1, 2007; 132(6): 1890 - 1897. [Abstract] [Full Text] [PDF]

				R. A. Johnston, M. Zhu, Y. M. Rivera-Sanchez, F. L. Lu, T. A. Theman, L. Flynt, and S. A. Shore Allergic Airway Responses in Obese Mice Am. J. Respir. Crit. Care Med., October 1, 2007; 176(7): 650 - 658. [Abstract] [Full Text] [PDF]