HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 102/1/468    most recent 00732.2006v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Petersson, J. Articles by Mure, M. Search for Related Content PubMed PubMed Citation Articles by Petersson, J. Articles by Mure, M.

INVITED REVIEW

HIGHLIGHTED TOPIC
Physiological Imaging of the Lung

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

¹Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna; ²Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet; ³Section of Nuclear Medicine, Department of Hospital Physics, Karolinska University Hospital Solna; and ⁴Medical Radiation Physics, Department of Oncology-Pathology, Stockholm University and Karolinska Institutet, Stockholm, Sweden

Emission tomography provides three-dimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the image-degrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be assessed within some percentage of the true value when relevant corrections are applied. SPECT is widely spread, and radiotracers are available that are easy to use and comparably inexpensive. Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. In contrast to some other methods, SPECT allows simultaneous imaging of more than one process, e.g., both regional blood flow and ventilation, for the whole lung. SPECT has been used to explore the influence of posture and clinical interventions on the spatial distribution of lung blood flow and ventilation. Lung blood flow is typically imaged using macroaggregates of albumin. Both radioactive gases and particulate aerosols labeled with radioactivity have been used for imaging of regional ventilation. However, all radiotracers are not equally suited for quantitative measurements; all have specific advantages and limitations. With SPECT, both blood flow and ventilation can be marked with radiotracers that remain fixed in the lung tissue, which allows tracer administration during conditions different from those at image registration. All SPECT methods have specific features that result from the used radiotracer, the manner in which it is administered, and how images are registered and analyzed.

respiratory physiology; regional blood flow; pulmonary ventilation; pulmonary gas exchange; radionuclide imaging

This article has been cited by other articles:

				A. Kozian, T. Schilling, F. Freden, E. Maripuu, C. Rocken, C. Strang, T. Hachenberg, and G. Hedenstierna One-lung ventilation induces hyperperfusion and alveolar damage in the ventilated lung: an experimental study Br. J. Anaesth., April 1, 2008; 100(4): 549 - 559. [Abstract] [Full Text] [PDF]

				J. Haller, D. Hyde, N. Deliolanis, R. de Kleine, M. Niedre, and V. Ntziachristos Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging J Appl Physiol, March 1, 2008; 104(3): 795 - 802. [Abstract] [Full Text] [PDF]