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Is the osmotically inactive sodium storage pool fixed or variable?

Division of Nephrology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California

Submitted 1 June 2006 ; accepted in final form 3 August 2006

ABSTRACT

Recently, there is renewed interest in the role of osmotically inactive Na⁺ storage during Na⁺ retention. Although it is well accepted that a portion of the total exchangeable Na⁺ reservoir is osmotically inactive, there is current controversy as to whether the osmotically inactive Na⁺ storage pool is fixed or variable during Na⁺ retention. In this article, we analyze the current scientific evidence to assess whether the osmotically inactive Na⁺ storage pool can be dynamically regulated. Our analysis supports the assertion that the osmotically inactive Na⁺ storage pool is fixed rather than variable.

exchangeable sodium