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J Appl Physiol 102: 276-285, 2007. First published September 28, 2006; doi:10.1152/japplphysiol.01436.2005
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Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials

Department of Physiological Sciences, University of Florida, Gainesville, Florida

Submitted 14 November 2005 ; accepted in final form 25 September 2006

The relationship between detection threshold of inspiratory resistive loads and the peaks of the respiratory-related evoked potential (RREP) is unknown. It was hypothesized that the short-latency and long-latency peaks of the RREP would only be elicited by inspiratory loads that exceeded the detection threshold. The detection threshold for inspiratory resistive loads was measured in healthy subjects with inspiratory-interruption or onset load presentations. In a separate protocol, the RREPs were recorded with resistive loads that spanned the detection threshold. The loads were presented in stimulus attend and ignore sessions. Onset and interruption load presentations had the same resistive load detection threshold. The P₁, N_f, and N₁ peaks of the RREP were observed with loads that exceeded the detection threshold in both attend and ignore conditions. The P₃₀₀ was present with loads that exceeded the detection threshold only in the attend condition. No RREP components were elicited with subthreshold loads. The P₁, N_f, and P₃₀₀ amplitudes varied with resistive load magnitude. The results support the hypothesis that there is a resistive load threshold for eliciting the RREPs. The amplitude of the RREP peaks vary as a function of load magnitude. The cognitive P₃₀₀ RREP peak is present only for detectable loads and when the subject attends to the stimulus. The absence of the RREP with loads below the detection threshold and the presence of the RREP elicited by suprathreshold loads are consistent with the gating of these neural measures of respiratory mechanosensory information processing.

respiratory sensation; somatosensory cortex; control of breathing; load detection

This article has been cited by other articles:

				Y. L. Chou and P. W. Davenport The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential J Appl Physiol, December 1, 2007; 103(6): 2012 - 2017. [Abstract] [Full Text] [PDF]