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Influence of acute plasma volume expansion on O₂ kinetics, O_2peak, and performance during high-intensity cycle exercise

¹Department of Exercise and Sport Science, Manchester Metropolitan University, Alsager; and ²Department of Anaesthesia, Wythenshawe Hospital, Manchester, United Kingdom

Submitted 7 February 2006 ; accepted in final form 9 May 2006

The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (O₂) kinetics, O_2peak, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed "step" cycle ergometer exercise tests at a work rate requiring 70% of the difference between the gas-exchange threshold and O_2max on three occasions: twice as a "control" (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 ± 1.0 vs. postinfusion: 14.7 ± 0.8 g/dl; P < 0.001) and hematocrit (preinfusion: 44 ± 2 vs. postinfusion: 41 ± 3%; P < 0.01). Despite this reduction in arterial O₂ content, APVE had no effect on O₂ kinetics (phase II time constant, Con: 33 ± 15 vs. APVE: 34 ± 12 s; P = 0.74), and actually resulted in an increased O_2peak (Con: 3.90 ± 0.56 vs. APVE: 4.12 ± 0.55 l/min; P = 0.006) and time to exhaustion (Con: 365 ± 58 vs. APVE: 424 ± 64 s; P = 0.04). The maximum O₂ pulse was also enhanced by the treatment (Con: 21.3 ± 3.4 vs. APVE: 22.7 ± 3.4 ml/beat; P = 0.04). In conclusion, APVE does not alter O₂ kinetics but enhances O_2peak and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects.

blood volume; endurance; O₂ kinetics; performance

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