Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 101: 618-627, 2006. First published April 27, 2006; doi:10.1152/japplphysiol.00252.2006
8750-7587/06 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
101/2/618    most recent
00252.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kubin, L.
Right arrow Articles by McCrimmon, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubin, L.
Right arrow Articles by McCrimmon, D. R.

INVITED REVIEW

HIGHLIGHTED TOPIC
Reflexes From the Lungs and Airways

Central pathways of pulmonary and lower airway vagal afferents

Leszek Kubin,1 George F. Alheid,2 Edward J. Zuperku,3 and Donald R. McCrimmon2

1Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 2Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and 3Research Service, Zablocki Veterans Affairs Medical Center and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Lung sensory receptors with afferent fibers coursing in the vagus nerves are broadly divided into three groups: slowly (SAR) and rapidly (RAR) adapting stretch receptors and bronchopulmonary C fibers. Central terminations of each group are found in largely nonoverlapping regions of the caudal half of the nucleus of the solitary tract (NTS). Second order neurons in the pathways from these receptors innervate neurons located in respiratory-related regions of the medulla, pons, and spinal cord. The relative ease of selective activation of SARs, and to a lesser extent RARs, has allowed for more complete physiological and morphological characterization of the second and higher order neurons in these pathways than for C fibers. A subset of NTS neurons receiving afferent input from SARs (termed pump or P-cells) mediates the Breuer-Hering reflex and inhibits neurons receiving afferent input from RARs. P-cells and second order neurons in the RAR pathway also provide inputs to regions of the ventrolateral medulla involved in control of respiratory motor pattern, i.e., regions containing a predominance of bulbospinal premotor neurons, as well as regions containing respiratory rhythm-generating neurons. Axon collaterals from both P-cells and RAR interneurons, and likely from NTS interneurons in the C-fiber pathway, project to the parabrachial pontine region where they may contribute to plasticity in respiratory control and integration of respiratory control with other systems, including those that provide for voluntary control of breathing, sleep-wake behavior, and emotions.

central pathways; C-fiber afferents; lung reflexes; rapidly adapting receptor; respiratory control; slowly adapting pulmonary stretch receptor


Address for reprint requests and other correspondence: D. R. McCrimmon, Dept. of Physiology-M211, Feinberg School of Medicine, Northwestern Univ., 303 E. Chicago Ave., Chicago, IL 60611-3008 (e-mail: dm{at}northwestern.edu)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. C. Andresen and J. H. Peters
Comparison of baroreceptive to other afferent synaptic transmission to the medial solitary tract nucleus
Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2032 - H2042.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. S. Segers, S. C. Nuding, T. E. Dick, R. Shannon, D. M. Baekey, I. C. Solomon, K. F. Morris, and B. G. Lindsey
Functional Connectivity in the Pontomedullary Respiratory Network
J Neurophysiol, October 1, 2008; 100(4): 1749 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. A. Rybak, R. O'Connor, A. Ross, N. A. Shevtsova, S. C. Nuding, L. S. Segers, R. Shannon, T. E. Dick, W. L. Dunin-Barkowski, J. M. Orem, et al.
Reconfiguration of the Pontomedullary Respiratory Network: A Computational Modeling Study With Coordinated In Vivo Experiments
J Neurophysiol, October 1, 2008; 100(4): 1770 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. V. Gourine, N. Dale, A. Korsak, E. Llaudet, F. Tian, R. Huckstepp, and K. M. Spyer
Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway
J. Physiol., August 15, 2008; 586(16): 3963 - 3978.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Mutolo, F. Bongianni, E. Cinelli, G. A. Fontana, and T. Pantaleo
Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R243 - R251.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
K. T. S. Pattinson
Opioids and the control of respiration
Br. J. Anaesth., June 1, 2008; 100(6): 747 - 758.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Gray
Transcription factors and the genetic organization of brain stem respiratory neurons
J Appl Physiol, May 1, 2008; 104(5): 1513 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. W. Bailey, S. M. Appleyard, Y.-H. Jin, and M. C. Andresen
Organization and Properties of GABAergic Neurons in Solitary Tract Nucleus (NTS)
J Neurophysiol, April 1, 2008; 99(4): 1712 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Y. Fong and J. T. Potts
Neurokinin-1 Receptors Modulate the Excitability of Expiratory Neurons in the Ventral Respiratory Group
J Neurophysiol, February 1, 2008; 99(2): 900 - 914.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K.-Z. Lee, D. D. Fuller, I-J. Lu, L.-C. Ku, and J.-C. Hwang
Pulmonary C-fiber receptor activation abolishes uncoupled facial nerve activity from phrenic bursting during positive end-expired pressure in the rat
J Appl Physiol, January 1, 2008; 104(1): 119 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. S. Moreira, A. C. Takakura, E. Colombari, and P. G. Guyenet
Activation of 5-Hydroxytryptamine Type 3 Receptor-Expressing C-Fiber Vagal Afferents Inhibits Retrotrapezoid Nucleus Chemoreceptors in Rats
J Neurophysiol, December 1, 2007; 98(6): 3627 - 3637.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. M. Appleyard, D. Marks, K. Kobayashi, H. Okano, M. J. Low, and M. C. Andresen
Visceral Afferents Directly Activate Catecholamine Neurons in the Solitary Tract Nucleus
J. Neurosci., November 28, 2007; 27(48): 13292 - 13302.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Xia, T. Damon, M. M. Niblock, D. Bartlett Jr., and J. C. Leiter
Unilateral microdialysis of gabazine in the dorsal medulla reverses thermal prolongation of the laryngeal chemoreflex in decerebrate piglets
J Appl Physiol, November 1, 2007; 103(5): 1864 - 1872.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. W. Bailey, S. M. Hermes, K. L. Whittier, S. A. Aicher, and M. C. Andresen
A-type potassium channels differentially tune afferent pathways from rat solitary tract nucleus to caudal ventrolateral medulla or paraventricular hypothalamus
J. Physiol., July 15, 2007; 582(2): 613 - 628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. C. Takakura, T. S. Moreira, G. H. West, J. M. Gwilt, E. Colombari, R. L. Stornetta, and P. G. Guyenet
GABAergic Pump Cells of Solitary Tract Nucleus Innervate Retrotrapezoid Nucleus Chemoreceptors
J Neurophysiol, July 1, 2007; 98(1): 374 - 381.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. S. Moreira, A. C. Takakura, E. Colombari, G. H. West, and P. G. Guyenet
Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors
J. Physiol., April 1, 2007; 580(1): 285 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Xia, T. A. Damon, J. C. Leiter, and D. Bartlett Jr.
Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets
J Appl Physiol, January 1, 2007; 102(1): 54 - 62.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. W. Bailey, S. M. Hermes, M. C. Andresen, and S. A. Aicher
Cranial Visceral Afferent Pathways through the Nucleus of the Solitary Tract to Caudal Ventrolateral Medulla or Paraventricular Hypothalamus: Target-Specific Synaptic Reliability and Convergence Patterns.
J. Neurosci., November 15, 2006; 26(46): 11893 - 11902.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Widdicombe
Reflexes from the lungs and airways: historical perspective
J Appl Physiol, August 1, 2006; 101(2): 628 - 634.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.