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J Appl Physiol 101: 60-67, 2006. First published March 30, 2006; doi:10.1152/japplphysiol.00085.2006
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Postnatal development of right atrial injection of capsaicin-induced apneic response in rats

Rurong Wang and Fadi Xu

Pathophysiology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico

Submitted 24 January 2006 ; accepted in final form 21 March 2006

Apnea and respiratory failure often occur in infants with pulmonary disease. Bronchopulmonary C-fiber (PCF)-mediated apnea is an important component of respiratory dysfunction. This study was undertaken to define the postnatal development of PCF-mediated apnea. The experiments were conducted in five groups of anesthetized, tracheotomized, and spontaneously breathing rats with ages at postnatal days P1–3, P7–9, P14–16, P21–23, and P56–58. Right atrial bolus injection of three doses of capsaicin (Cap), equivalent to 2, 4, and 8 µg/kg used previously in 450-g rats, was applied to stimulate PCFs. We found that 1) Cap-induced apneic response [percent change from the baseline expiratory duration (TE) values ({Delta}TE%)] and the sensitivity of this response ({Delta}TE%·µg–1) were significantly greater in the rats <P10 than those >P10; 2) the Cap-induced apneas were vagally dependent in all rats tested; and 3) bivagotomy-induced prolongation of TE was much greater in the rats <P10 than those >P10. From these findings we concluded that, compared with the older rats (>P10), the newborn rats have a stronger PCF-mediated respiratory inhibition that may contribute to infants' vulnerability to respiratory failure.

bronchopulmonary C fibers; immaturity; age; apnea


Address for reprint requests and other correspondence: F. Xu, Lovelace Respiratory Research Institute, Pathophysiology Program, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108 (e-mail: fxu{at}lrri.org)




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W. Peng, J. Zhuang, K. S. Harrod, and F. Xu
Respiratory syncytial virus infection in anesthetized weanling rather than adult rats prolongs the apneic responses to right atrial injection of capsaicin
J Appl Physiol, June 1, 2007; 102(6): 2201 - 2206.
[Abstract] [Full Text] [PDF]


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