HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 101/1/316    most recent 01363.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Paton, C. M. Articles by Hagberg, J. M. Search for Related Content PubMed PubMed Citation Articles by Paton, C. M. Articles by Hagberg, J. M.

TRANSLATIONAL PHYSIOLOGY

Hemostatic response to postprandial lipemia before and after exercise training

Department of Kinesiology, University of Maryland, College Park, Maryland

Submitted 26 October 2005 ; accepted in final form 17 February 2006

ABSTRACT

Chronic hypertriglyceridemia is thought to be atherogenic and is associated with an elevated thrombotic potential, both of which may be improved with aerobic exercise training. Eight subjects were tested for aerobic capacity, body composition, and postprandial lipemia (PPL), followed by 6 mo of exercise training and final testing. Blood samples were obtained for measurement of free fatty acid (FFA), triglycerides (TG), insulin (Ins), and glucose (Glu). Hemostatic variables including factor VII activity (FVIIa), tissue factor pathway inhibitor-factor Xa complex (TFPI/Xa), and plasminogen activator inhibitor-1 (PAI-1) antigen/activity as well as leukocyte tumor necrosis factor- (TNF-) gene expression were determined among four subjects. We found that the exercise training was of sufficient intensity to increase aerobic capacity (P < 0.0001) and improve body composition (P = 0.04). There were no differences between tests among PPL responses of FFA, TG, Ins, or Glu; however, the mean TG response and fat oxidation rate improved. PAI-1 antigen/activity, FVIIa, TFPI/Xa, and TNF- gene expression were all improved after exercise training after adjusting for confounders. We conclude that aerobic exercise training reduces the potential for coagulation, improves fibrinolytic potential, and reduces leukocyte TNF- gene expression after the ingestion of a high-fat meal.

coagulation

This article has been cited by other articles:

				A. Singhal, J. L. Trilk, N. T. Jenkins, K. A. Bigelman, and K. J. Cureton Effect of intensity of resistance exercise on postprandial lipemia J Appl Physiol, March 1, 2009; 106(3): 823 - 829. [Abstract] [Full Text] [PDF]

				L. Jensen, B. Sloth, I. Krog-Mikkelsen, A. Flint, A. Raben, T. Tholstrup, N. Brunner, and A. Astrup A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women Am. J. Clinical Nutrition, January 1, 2008; 87(1): 97 - 105. [Abstract] [Full Text] [PDF]