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INVITED REVIEW
HIGHLIGHTED TOPICS
Regulation of the Cerebral Circulation
Departments of Internal Medicine and Pharmacology and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Reactive oxygen species have multiple effects on vascular cells. Defining the sources and the impact of the various reactive oxygen species within the vessel wall has emerged as a major area of study in vascular biology. This review will focus on recent findings related to effects of reactive oxygen species on cerebral vascular tone. Effects of superoxide radical, hydrogen peroxide, and the reactive nitrogen species peroxynitrite are summarized. Although higher concentrations may be important for cerebral vascular biology in disease, relatively low concentrations of reactive oxygen species may function as signaling molecules involved with normal regulation of cerebral vascular tone. The mechanisms by which reactive oxygen species affect vascular tone may be quite complex, and our understanding of these processes is increasing. Additionally, the role of reactive oxygen species as mediators of endothelium-dependent relaxation is addressed. Finally, the consequences of the molecular interactions of superoxide with nitric oxide and arachidonic acid are discussed.
endothelium; hydrogen peroxide; superoxide; nitric oxide; oxidative stress; endothelium-derived hyperpolarizing factor; peroxynitrite
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