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J Appl Physiol 100: 107-111, 2006. First published September 1, 2005; doi:10.1152/japplphysiol.00575.2005
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Nasal wall compliance in vasomotor rhinitis

Jean-François Papon,1,3 Lydia Brugel-Ribere,3 Redouane Fodil,1 Céline Croce,1 Christian Larger,2 Michel Rugina,3 André Coste,1,3 Daniel Isabey,1 Françoise Zerah-Lancner,2 and Bruno Louis1

1Physiopathologie et Thérapeutique Respiratoires INSERM UMR 651; 2Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor (Assistance Publique-Hôpitaux de Paris); and 3Service d'ORL et de Chirurgie Cervico-Faciale des hôpitaux Intercommunal et Henri Mondor (Assistance Publique-Hôpitaux de Paris), Créteil, France

Submitted 16 May 2005 ; accepted in final form 29 August 2005

Nasal compliance is a measure related to the blood volume in the nasal mucosa. The objective of this study was to better understand the vascular response in vasomotor rhinitis by measuring nasal cross-sectional area and nasal compliance before and after mucosal decongestion in 10 patients with vasomotor rhinitis compared with 10 healthy subjects. Nasal compliance was inferred by measuring nasal area by acoustic rhinometry at pressures ranging from atmospheric pressure to a negative pressure of –10 cmH2O. Mucosal decongestion was obtained with one puff per nostril of 0.05% oxymetazoline. At atmospheric pressure, nasal cross-sectional areas were similar in the vasomotor rhinitis group and the healthy subject group. Mucosal decongestion did not induce any decrease of nasal compliance in patients with vasomotor rhinitis in contrast with healthy subjects. Our results support the hypothesis, already proposed, of an autonomic dysfunction based on a paradoxical response of the nasal mucosa in vasomotor rhinitis. Moreover, the clearly different behavior between healthy subjects and vasomotor rhinitis subjects suggests that nasal compliance measurement may therefore represent a potential line of research to develop a diagnostic tool for vasomotor rhinitis, which remains a diagnosis of exclusion.

acoustic rhinometry; nasal physiology; oxymetazoline


Address for reprint requests and other correspondence: B. Louis, INSERM U651, Faculté de médecine, 8 rue du général Sarrail, 94010 Créteil Cedex, France (e-mail: bruno.louis{at}creteil.inserm.fr)






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