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J Appl Physiol 10: 459-460, 1957;
8750-7587/57 $5.00
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Effect of Methimazole on Size of the Heart in the Rat

Edward J. Van Liere 1 and David W. Northup 1

1 From the Department of Physiology, School of Medicine, West Virginia University, Morgantown, West Virginia

Thirteen rats were given methimazole, 0.11 mg/ml, in their drinking water for 45 days; 12 rats served as controls. The methimazole-treated rats showed a reduction of the metabolic rate and a decline in the heart-weight/body-weight ratio. The spleen and adrenal also showed a decline in weight. All these changes were statistically significant.

Submitted on August 8, 1956






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