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J Appl Physiol 10: 267-270, 1957;
8750-7587/57 $5.00
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Minimum Urine Total Solute Concentration in Response to Water Loading in Normal Men

Edgar J. Schoen 1

1 From the Department of Pediatrics, Kaiser Foundation Hospital, Oakland, California

A quantitative study of the diluting power of the kidneys, based on 31 water-loading experiments in 10 normal men, is reported. A minimum urine total solute concentration (MUC) of 59 mOs/l. was observed, with a range of 37 to 80 mOs/l. The MUC appears to be independent of the size of the water load when the load exceeds a minimum level (1000–1500 ml). Further increase in water intake only extends the period of minimum urine total solute concentration.

Submitted on September 4, 1956






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