Journal of Applied Physiology
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J Appl Physiol 10: 98-102, 1957;
8750-7587/57 $5.00
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Effects of Massive Doses of Vitamin D on Physiological Behavior of Calcium in Cattle

H. R. Conrad 1 and Sam L. Hansard 1

1 From the University of Tennessee-Atomic Energy Commission, Agricultural Research Program, Oak Ridge, Tennessee

Tracer doses of calcium-45 were used as markers in conjunction with balance trials, blood and tissue distribution studies with paired Hereford calves to assess changes in calcium metabolism when 5 million units of vitamin D were fed for 5-day period. The true digestibility of calcium was increased, denoting increased absorption and confirming the findings reported by others. Increased absorption due to vitamin D feeding was accompanied by several related effects, including decreased endogenous fecal losses, a transitory increase in absorbed radiocalcium in the blood, more rapid movement of radiocalcium through the plasma, a threefold increase in net calcium retention and increased deposition of radiocalcium in areas of new bone growth. Extended feeding of vitamin D for two additional 5-day periods produced no apparent deleterious effect on calcium metabolism. Increased calcium concentration in the kidney and esophagus was observed but had disappeared after 8 days of vitamin D feeding. Autoradiographs of femur bone sections indicated that deposited radiocalcium in the areas of new bone growth was exchanged more rapidly under conditions of extended vitamin D feeding. Analytical data supported these observations.

Submitted on June 22, 1956




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